The possible end to Painful Sunburn

We all know that sunburn is painful but that may become a thing of the past.Researchers have identified a molecule in the skin that is largely to blame for the painful effects of staying too long in the sun.

Scientists say, That a new discovery could lead to treatments that could bring an end to the pain of sunburn. They found that by blocking the molecules, called TRPV4, they could provide a way to combat the burning sensation and possibly several other causes of pain.

Dr Wolfgang Liedtke, from Duke University School
of Medicine said,

We have uncovered a novel explanation for why sunburn hurts and If we understand sunburn better, we can understand pain better.

Most cases of sunburn are caused by ultraviolet B (UVB) radiation.
In moderation, this component of sunlight benefits the body by
boosting levels of vitamin D.But too strong a dose of UVB can damage DNA in skin cells, increasing susceptibility to cancer. Sunburn is nature’s way of telling us to find some shade.

Dr Liedtke’s team genetically engineered mice to lack TRPV4 in their
skin and exposed their hind paws – which most resemble human skin –
to UVB rays. The mutant mice suffered little sensitisation and tissue injury, while normal animals became hypersensitive and blistered.

The scientists Then produced a drug that selectively inhibits the
molecule and applied it to the paws of normal mice in a solution of
alcohol and glycerol.The then treated mice were largely resistant to the pain-inducing and skin-damaging effects of sunburn.

Research on human skin samples has shown increased activation of
TRPV4 after UVB exposure.

The researchers findings are reported in the journal
Proceedings of the National Academy of Sciences. They say more work is needed but envisage sun screens containing TRPV4-blockers to protect against burning.

Dr Liedtke said

I think we should be cautious because we want to see what inhibition of TRPV4 will do to other processes going on in the skin. Once these concerns are addressed, we will need to adapt TRPV4 blockers to make them more suitable for topical application. I could imagine it being mixed with traditional sunblock to provide stronger
protections against UVB exposure.

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